MOTS-c (Human)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a potent, naturally occurring 16-amino acid signaling peptide encoded by the mitochondrial genome. In the field of advanced metabolic research and geroscience, MOTS-c is highly distinguished for its role as a “mitochondrial hormone” that coordinates communications between mitochondria and the nucleus. Its primary mechanism involves the activation of the AMPK (AMP-activated protein kinase) pathway and the promotion of AICAR levels, which collectively enhance glucose uptake and fatty acid oxidation. It provides researchers with a robust experimental tool to investigate metabolic flexibility, insulin sensitivity, and cellular longevity signaling across various tissue models.

Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Molecular Weight: 2174.62 g/mol
Molecular Formula: C101H152N28O22S2
Purity: ≥ 99%
Storage: 2-8°C (Short-term) | -20°C (Long-term / Up to 24 months)