Dulaglutide

Dulaglutide is a high-purity, synthetic fusion protein that functions as a potent Glucagon-Like Peptide-1 (GLP-1) receptor agonist. In the field of advanced metabolic research, Dulaglutide is distinguished by its innovative molecular architecture: it consists of two identical chains of a GLP-1 analog, modified to resist DPP-4 degradation, each covalently linked to a modified human immunoglobulin G4 (IgG4) Fc fragment. This fusion significantly increases its molecular size and reduces renal clearance, resulting in a prolonged biological half-life. It provides researchers with a robust experimental model to investigate glucose-dependent insulin secretion, the inhibition of inappropriate glucagon release, and the molecular mechanisms of delayed gastric emptying and appetite suppression.

Chemical Name: Dulaglutide
Synonyms: N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(furan-2-yl)imidazo[1,2-a]pyridin-3-amine;Imidazo[1,2-a]pyridin-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(2-furanyl)-
Molecular Formula: C19H15N3O3
Molecular Weight: 333.34