PE-22-28 × 10 Vials

PE-22-28 is a synthetic derivative of spadin, a peptide derived from sortilin, studied for its potential role as an antagonist of the TREK-1 (TWIK-related potassium) channel. TREK-1 modulation is of significant interest in neurological research, particularly in models of depression, neurogenesis, and cognitive function.

Preclinical studies indicate that PE-22-28 may enhance neurogenesis and synaptogenesis in the hippocampus, potentially promoting neuronal growth, synaptic connectivity, and mood stabilization. The peptide has been reported to exhibit enhanced stability and rapid onset of action compared to native spadin, positioning it as a promising tool in research on depressive disorders, post-stroke depression, and nootropic effects.

Chemical Formula: C₃₅H₅₅N₁₁O₉
Molecular weight: 773.8947 g/mol
Peptide Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.